If you are above 50 I would say go with the Merc. its basically the Ford Taurus of Germany though. Lived there for four years and the E series is a Taxi cab over there. Albeit a nice taxi, its a taxi. The coupe looks sporty but when a mechanic sees you roll up he has no reason to believe you need a break on the repair costs.
I own an 08' G37 coupe and if I had to switch to an E class it would have to be an 08 and up E63 AMG. I got hammered on a long straight by one in my 350Z vert but ate his lunch in the corners.
The E350 looks great but its not as much a sports car as it is for cruising on a pretty couch.

 

Also keep in mind the G is not very comfortable for anyone much over 5'8" tall or weighing over about 190 lbs.

 

Pic of the E350 is a few posts up.

As for the G, there was another 2012 model, colors I wouldn't have wanted myself, for which they were asking $40k. Fewer than 10,000 miles. For some reason, couldn't bring myself to consider that over the E350 which was a 2010, over 20,000 miles, but CPO, and which I purchased at a lower sticker price (as well as with a better interest rate than I suspect I would have gotten with the G37).

I'm a young guy in a solid profession, so I'm probably on the young end of the car's demographic if in it at all.

 

Not true .... 6'3" and 230lbs here and I'm just fine.

 

^ +1. 6', 200lbs here and love the fit of the sport seats. Never had any complaints in the comfort department.

 

I disagree. I'm 6'2" & 185, my dad weighs 300 and change, is 6'2", and we both love it.

 

6'3", 200lbs.... no prob in an '08 G37s

 

Nice to see we have some members of the "Big Man's Club" here :-)

 

^ experienced that myself this past year and I have to say it but it is a pita to deal with. Getting to the dealership with a broken car that far away can prove challenging and towing costs will definitely be on the high side(although I have gotten the dealership to cover my towing cost once). Not the biggest deal in the world but you should keep it in mind.

 

i test drove an E550 and still was more impressed by the power and handling of the G37s.

 

It's been refuted, but I am 6ft and 175 pounds. I find mine comfortable and spacious. (08 G37s coupe)

 

If you are concerned about a "status car" then go with Mercedes. Take into consideration like others have said maintenance is pricey. If you are more concerned about reliability, low total cost of ownership and and a car that performs and handles well go with the G.

 

Great answer! I will research cars but never in a forum where the opinion is going to be biased. Thats just silly.

 

Went from a Crossfire SRT6 (mercedes engine) loved the car but feared the maintenance cost after warranty was close to ending. Traded to Lancer to save on gas but missed the sports coupe. Came back to the darkside G37. Get the Infinti and dont look back.