2001 Acura CL-S wore tires flat as a pool table, 2003 IS300 wore inside edges, a lot, no matter what alignment settings were used and the 2011 G37 is wearing inside edges more than the rest of the tire. Alignment needed or is this just the way the G wears tires?

 

alignment has, almost always, a direct effect on tire wear. "IS300 wore inside edges, a lot, no matter what alignment settings were used" i do not believe... unless you had an accident that damaged the suspension.

you are getting camber wear and it can be reduced with a proper alignment

 

Should be able to get the alignment set so you're wearing evenly, the summer Bridestones tend to wear so fast that it won't take much mis-alignment to show the wear. I'm on my 2nd G and both had camber, toe & caster well in spec w/ very even treadwear. I'm dropped to zero gap now and still very even wear (w/ similar alignment settings).

 

Pics would help as well if you have any. Suspecting alignment, more than likely camber.